Rs2459976 in ZW10 gene associated with congenital heart diseases in Chinese Han population

Abstract

Congenital heart diseases (CHD) are a large group of prevalent and complex anatomic malformations of the heart, with the genetic basis remaining largely unknown. Since genes or factors associated with the differentiation of human embryonic stem (HES) cells would affect the development of all embryonic tissues, including cardiac progenitor cells, we postulated their potential roles in CHD. In this study, we focused on ZW10, a kinetochore protein involved in the process of proper chromosome segregation, and conducted comparative studies between CHD patients and normal controls matched in gender and age in Chinese Han populations. We identified three variations in the ZW10 gene, including rs2885987, rs2271261 and rs2459976, which all had high genetic heterozygosity. Association analysis of these genetic variations with CHD showed correlation between rs2459976 and the risk of CHD. We conclude that rs2459976 in the ZW10 gene is associated with CHD in Chinese Han populations.

Keywords: ASD; SNP; ZW10; congenital heart disease; human embryonic stem cells.

Figure 1. Schematic diagramoflocations of ZW10 gene SNPsrs2885987, rs11605483, rs2271261, rs2271796 and rs2459976

Figure 2. LD analysis of the variants rs2885987, rs2271261 and rs2459976 in the ZW10 gene

The LD plots were generated using the Haploview software v4.2. (A) Data analysis between CHD patients and controls from the present study of variants in ZW10 gene; (B) Data from HapMap CHB of variants in ZW10 gene. The data from the HapMap CHB and this work were consistent.