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Review
. 2018 Jan 30:7:2.
doi: 10.1186/s40035-018-0107-y. eCollection 2018.

Alzheimer's disease hypothesis and related therapies

Xiaoguang Du  1 , Xinyi Wang  1 , Meiyu Geng  2
Affiliations
Review

Alzheimer's disease hypothesis and related therapies

Xiaoguang Du et al. Transl Neurodegener. .

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of twisted fibers of tau proteins inside neurons, cholinergic neuron damage, inflammation, oxidative stress, etc., and many anti-AD drugs based on these hypotheses have been developed. In this review, we will discuss the existing and emerging hypothesis and related therapies.

Keywords: Alzheimer’s disease - complicated disease - anti-AD drugs; Hypothesis about AD.

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Conflict of interest statement

Not relevant.Not applicable.The authors declare they have no competing interests.

References

    1. Ali G-C, Guerchet M, Wu Y-T, Prince M, Prina M. Chapter 2: The global prevalence of dementia. In: Prince M, Guerchet M, Ali G-C, Wu Y-T, Prina M, editors. The Global Impact of Dementia. An analysis of prevalence, incidence, cost and trends. London: Alzheimer’s Disease International (ADI); 2015. p. 10–29.
    1. Cummings J, et al. Drug development in Alzheimer’s disease: the path to 2025. Alzheimers Res Ther. 2016;8:39. doi: 10.1186/s13195-016-0207-9. - DOI - PMC - PubMed
    1. Vassar R, Citron M. Abeta-generating enzymes: recent advances in beta- and gamma-secretase research. Neuron. 2000;27(3):419–422. doi: 10.1016/S0896-6273(00)00051-9. - DOI - PubMed
    1. van Es JH, et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 2005;435(7044):959–963. doi: 10.1038/nature03659. - DOI - PubMed
    1. Olry A, et al. Generation and characterization of mutant cell lines defective in gamma-secretase processing of notch and amyloid precursor protein. J Biol Chem. 2005;280(31):28564–28571. doi: 10.1074/jbc.M502199200. - DOI - PubMed