Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2018 Mar;11(2):98-99.
doi: 10.1111/cts.12538. Epub 2018 Feb 9.

It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm

Valentina Shakhnovich  1
Affiliations
Editorial

It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm

Valentina Shakhnovich. Clin Transl Sci. 2018 Mar.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Reverse translation research paradigm. Republished with permission from Wagner, J.A. Patient‐centered reverse translation. Clin. Pharmacol. Ther. (2017). https://doi.org/10.1002/cpt.902.
See this image and copyright information in PMC

References

    1. Ledford, H. Translational research: the full cycle. Nature 453, 843–845 (2008). - PubMed
    1. McWilliam, S.J. , Antoine, D.J. & Pirmohamed, M. Repurposing statins for renal protection: is it a class effect? Clin. Transl. Sci. 11, 100–102 (2018). - PMC - PubMed
    1. Kurani, S. , Theel, E. , Greenberg‐Worisek, A . Diagnostic testing for Zika: observing rapid translation during a public health emergency. Clin. Transl. Sci. 11, 103–105 (2018). - PMC - PubMed
    1. Becker, M.L. & Funk, R.S. Reverse translation in advancing pharmacotherapy in pediatric rheumatology: a logical approach in rare diseases with limited resources. Clin. Transl. Sci. 11, 106–108 (2018). - PMC - PubMed
    1. Faucette, S. , Wagh, S. , Trivedi, A. , Venkatakrishnan, K. & Gupta, N. Reverse translation of US Food and Drug Administration reviews of oncology new molecular entities approved in 2011‐2017: lessons learned for anticancer drug development. Clin. Transl. Sci. 11, 123–146 (2018). - PMC - PubMed

Publication types

LinkOut - more resources