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. 1986 May-Jun;14(3):142-4.
doi: 10.1007/BF01643481.

In vitro susceptibility of aerobic gram-negative blood culture isolates to oxolinic acid, norfloxacin, ciprofloxacin, enoxacin, pefloxacin, ofloxacin and oxo-enoxacin

P Van der Auwera

In vitro susceptibility of aerobic gram-negative blood culture isolates to oxolinic acid, norfloxacin, ciprofloxacin, enoxacin, pefloxacin, ofloxacin and oxo-enoxacin

P Van der Auwera. Infection. 1986 May-Jun.

Abstract

100 gram-negative strains isolated from blood cultures were selected for the evaluation of the in vitro activity of oxolinic acid, norfloxacin, ciprofloxacin, enoxacin, pefloxacin, ofloxacin and oxo-enoxacin. Ciprofloxacin showed the highest intrinsic activity. Oxo-enoxacin, the major metabolite of enoxacin, was 10-15-fold less active than enoxacin. Against Enterobacteriaceae and Vibrionaceae, all fluorinated quinolones except norfloxacin were equally effective, while against non-fermenters, ciprofloxacin and ofloxacin demonstrated greater activity than the others. Resistance to oxolinic acid had a detrimental effect on susceptibility to the new fluorinated quinolones.

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References

    1. Antimicrob Agents Chemother. 1983 Nov;24(5):784-6 - PubMed
    1. Antimicrob Agents Chemother. 1983 Apr;23(4):559-64 - PubMed
    1. Arzneimittelforschung. 1985;35(3):570-2 - PubMed
    1. Eur J Clin Microbiol. 1983 Apr;2(2):111-5 - PubMed
    1. Antimicrob Agents Chemother. 1984 Jul;26(1):17-9 - PubMed

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