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Comment
. 2018 Feb 8;172(4):638-640.
doi: 10.1016/j.cell.2018.01.024.

Building a Stable Relationship: Ensuring Homeostasis among Cell Types within a Tissue

Nicholas W Frankel  1 , Wendell A Lim  2
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Building a Stable Relationship: Ensuring Homeostasis among Cell Types within a Tissue

Nicholas W Frankel et al. Cell. .

Abstract

Many processes controlling cell growth and death are well characterized for individual cell lineages, but how ensembles of different cell types in a tissue regulate collective size and composition remains unclear. In this issue of Cell, Zhou et al. employ experiments and theory to uncover design principles of tissue homeostasis arising from cross-talk between fibroblasts and macrophages.

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  • Circuit Design Features of a Stable Two-Cell System.
    Zhou X, Franklin RA, Adler M, Jacox JB, Bailis W, Shyer JA, Flavell RA, Mayo A, Alon U, Medzhitov R. Zhou X, et al. Cell. 2018 Feb 8;172(4):744-757.e17. doi: 10.1016/j.cell.2018.01.015. Epub 2018 Feb 1. Cell. 2018. PMID: 29398113 Free PMC article.