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Meta-Analysis
. 2018 Feb 9;16(1):13.
doi: 10.1186/s12958-018-0324-3.

Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis

Jing Zhao  1 , Xi Huang  1 , Bin Xu  1 , Yi Yan  1 , Qiong Zhang  1 , Yanping Li  2
Affiliations
Meta-Analysis

Whether vitamin D was associated with clinical outcome after IVF/ICSI: a systematic review and meta-analysis

Jing Zhao et al. Reprod Biol Endocrinol. .

Abstract

Background: There exist contradictive views on whether the vitamin D has association with clinical outcome of in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI). The present meta-analysis aim to establish whether vitamin D was associated with clinical outcomes of IVF/ICSI.

Methods: MEDLINE, Google Scholar and the Cochrane Library from database inception to March 2017 were searched. Clinical studies, which evaluated the association of vitamin D level and the clinical outcomes after IVF/ICSI, were included. The Main Outcome Measures were clinical pregnancy, ongoing pregnancy, and live birth.

Results: In the analysis of clinical pregnancy, 9 cohort studies were included. Of which, 2 studies and 3 studies were identified in analyzing ongoing pregnancy and live birth, respectively. Meta-analysis showed trends toward lower clinical pregnancy [RR 0.91, (95% CI 0.77-1.07)] and higher ongoing pregnancy [RR 1.06, (95% CI 0.95-1.19)] for women with deficient level of vitamin D. The probability of live birth for women with deficient level of vitamin D was significantly lower than cases with sufficient level of vitamin D [RR 0.74, (95% CI 0.58-0.90)].

Conclusions: Deficient vitamin D was associated with decreased probability of live birth after IVF/ICSI. So vitamin D should be supplied to women with deficient level vitamin D.

Keywords: Assisted reproduction technology; Clinical pregnancy; Live birth; Vitamin D.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Flow chart showing study selection process
Fig. 2
Fig. 2
Forest plot showing the results of meta-analysis of studies comparing the effect of deficient vitamin D and sufficient vitamin D on clinical pregnancy after IVF/ICSI
Fig. 3
Fig. 3
Forest plot showing the results of meta-analysis of studies comparing the effect of deficient vitamin D and sufficient vitamin D on ongoing pregnancy after IVF/ICSI
Fig. 4
Fig. 4
Forest plot showing the results of meta-analysis of studies comparing the effect of deficient vitamin D and sufficient vitamin D on live birth after IVF/ICSI
See this image and copyright information in PMC

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