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Observational Study
. 2018 Jul-Aug;38(4):401-413.
doi: 10.1016/j.nefro.2017.11.025. Epub 2018 Feb 7.

Chronic renal disease in spain: prevalence and related factors in persons with diabetes mellitus older than 64 years

[Article in English, Spanish]
Juan Martínez Candela  1 , Javier Sangrós González  2 , Francisco Javier García Soidán  3 , José Manuel Millaruelo Trillo  2 , Javier Díez Espino  4 , Daniel Bordonaba Bosque  5 , Luis Ávila Lachica  6 ; en representación del Grupo de Atención Primaria y Prediabetes de la Sociedad Española de Diabetes
Affiliations
Free article
Observational Study

Chronic renal disease in spain: prevalence and related factors in persons with diabetes mellitus older than 64 years

[Article in English, Spanish]
Juan Martínez Candela et al. Nefrologia (Engl Ed). 2018 Jul-Aug.
Free article

Abstract

Introduction: Type 2 diabetes mellitus and chronic kidney disease (CKD) are conditions which have a high prevalence in individuals ≥ 65 years of age and represent a major public health problem.

Objectives: To determine the prevalence of CKD, its categories and its relationship with various demographic and clinical factors in elderly patients with type 2 diabetes mellitus in Spain.

Methods: Observational, cross-sectional, multicenter, Spanish epidemiological study. Patients with known type 2 diabetes mellitus, age ≥ 65 years of age treated in Primary Care were included. We collected demographic, anthropometric and analytical variables from the previous 12 months, including the albumin-to-creatinine ratio and estimated glomerular filtration rate to evaluate renal function.

Results: The prevalence of CKD was 37.2% (95% CI, 34.1-40.3%), renal failure was 29.7% (95% CI, 26.8-32.6%) and increased albuminuria was 20.6% (95% CI, 17.3-23.9%), moderately increased albuminuria was 17.8% (95% CI, 14.7-20.9%) and severely increased albuminuria was 2.8% (95% CI, 1.4-4.2%). In turn, the prevalence of CKD categories were: G1 1.3% (95% CI, 0.6-2%), G2 6.2% (95% CI, 4.6-7.8%), G3a 17.2% (95% CI, 14.8-19.6%), G3b 9.8% (95% CI, 7.9-11.7%), G4 2% (95% CI, 1.1-2.9%) and G5 0.7% (95% CI, 0.2-1.2%). In the multivariate analysis, after adjusting for the remaining variables, CKD was associated with elderly age (OR 5.13, 95% CI, 3.15-8.35), high comorbidity (OR 3.36. 95% CI, 2.2-5.12) and presence of antihypertensive treatment (OR 2.43. 95% CI, 1.48-4.02).

Conclusions: CKD is frequent in the diabetic population ≥ 65 years of age and is associated with elderly age, high comorbidity and with treated hypertension. No relationship has been found with gender and time in years since onset of diabetes.

Keywords: Categories, elderly; Categorías, ancianos; Chronic kidney disease; Comorbidity; Comorbilidad; Dependence; Dependencia; Diabetes mellitus tipo 2; Enfermedad renal crónica; Type 2 diabetes mellitus.

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