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Review
. 2018 Apr:100:198-204.
doi: 10.1016/j.biopha.2018.01.108. Epub 2018 Feb 16.

Immune cells involved in the pathogenesis of ankylosing spondylitis

Alireza Rezaiemanesh  1 , Mohsen Abdolmaleki  2 , Kamal Abdolmohammadi  2 , Hamideh Aghaei  2 , Fatemeh Dadgar Pakdel  2 , Yousef Fatahi  3 , Narjes Soleimanifar  4 , Mahdi Zavvar  2 , Mohammad Hossein Nicknam  5
Affiliations
Review

Immune cells involved in the pathogenesis of ankylosing spondylitis

Alireza Rezaiemanesh et al. Biomed Pharmacother. 2018 Apr.

Abstract

Ankylosing spondylitis (AS) is an inflammatory autoimmune disease. AS is a prototype form of spondyloarthropathies (SpA). The precise etiology of AS has not been fully understood. But Inflammation has a critical role in the pathogenesis of the disease. The immune system by various cells, secreted-mediators and markers manage and regulate the immune responses and inflammation. Every factor which disturbed this regulation and hemostasis can cause chronic inflammation. In this review, we discussed the role of several innate and adaptive immune cells involved in the triggering, initiation, development, and regulation of AS.

Keywords: Ankylosing spondylitis; Cytokines; Immune cells; Inflammation.

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