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. 2018 Mar;135(3):485-488.
doi: 10.1007/s00401-018-1820-4. Epub 2018 Feb 10.

Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

Melike Pekmezci  1 , Meredith Stevers  1 , Joanna J Phillips  1   2 , Jessica Van Ziffle  1   3 , Boris C Bastian  1   3 , Nadejda M Tsankova  4 , Bette K Kleinschmidt-DeMasters  5 , Marc K Rosenblum  6 , Tarik Tihan  1 , Arie Perry  1   2 , David A Solomon  7   8
Affiliations

Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway

Melike Pekmezci et al. Acta Neuropathol. 2018 Mar.
No abstract available

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Conflict of interest statement

Conflict of interest

The authors declare that they have no competing interests related to this study.

Figures

Figure 1.
Figure 1.
Multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) is defined by genetic alterations that activate the MAP kinase signaling pathway. a, Table of the clinicopathologic features of the eight patients with MVNT and the pathogenic genetic alterations identified in this study. b-e, Pre-operative axial (b-c) and coronal (d-e) T2-weighted magnetic resonance imaging for patient MVNT #1. fg, H&E staining (f) and phospho-ERK immunostaining (g) on MVNT #7. h, Snapshot from the Integrated Genome Viewer for MVNT #7 showing sequencing reads containing a small in-frame deletion in exon 2 of the MAP2K1 gene.
See this image and copyright information in PMC

References

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