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Comment
. 2018 Feb:8:211-213.
doi: 10.1016/j.molmet.2018.01.001. Epub 2018 Jan 9.

Central leptin and autonomic regulation: A melanocortin business

Miguel López  1
Affiliations
Comment

Central leptin and autonomic regulation: A melanocortin business

Miguel López. Mol Metab. 2018 Feb.
No abstract available

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Figures

Figure 1
Figure 1
Central leptin modulates the autonomic nervous system through POMC and AgRP neurons in the ARC. Central leptin acts in the hypothalamus to modulate the autonomic nervous system (ANS) activity innervating several organs and tissues A recent manuscript from Rahmouni and colleagues has demonstrated that proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARC) differentially modulate the two branches of the ANS, namely the sympathetic (SNS) and parasympathetic (PSNS) nervous system subserving brown and white adipose tissue (BAT and WAT), liver, gut, lumbar skeletal muscle and kidney. ARC neurons evoke those effects by modulating pre-autonomic sympathetic and parasympathetic neurons in other nuclei, such as the paraventricular (PVH), the dorsomedial (DMH) and the ventromedial (VMH). The leptin-evoked effect on the sympathetic innervation of adrenal gland is independent of POMC and AgRP neurons.
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References

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