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. 2017 Dec 22;7(3):454-462.
doi: 10.1159/000485177. eCollection 2017 Sep-Dec.

Decreased Muscle Strength and Quality in Diabetes-Related Dementia

Akito Tsugawa  1 , Yusuke Ogawa  1 , Naoto Takenoshita  1 , Yoshitsugu Kaneko  1 , Hirokuni Hatanaka  1 , Eriko Jaime  1 , Raita Fukasawa  1 , Haruo Hanyu  1
Affiliations

Decreased Muscle Strength and Quality in Diabetes-Related Dementia

Akito Tsugawa et al. Dement Geriatr Cogn Dis Extra. .

Abstract

Background/aims: Diabetes-related dementia (DrD), a dementia subgroup associated with specific diabetes mellitus (DM)-related metabolic abnormalities, is clinically and pathophysiologically different from Alzheimer disease (AD) and vascular dementia. We determined whether skeletal muscle strength, quality, and mass decrease in individuals with DrD.

Methods: We evaluated grip and knee extension strength, muscle mass, and gait speed in 106 patients with probable AD and without type 2 DM (AD[-DM] group), 74 patients with probable AD and with DM (AD[+DM] group), and 36 patients with DrD (DrD group). Muscle quality was defined as the ratio of muscle strength to muscle mass.

Results: Both female and male subjects with DrD showed significantly decreased muscle strength and quality in the upper extremities compared with the subjects with AD[-DM] or AD[+DM]. Female subjects with DrD showed significantly decreased muscle quality in the lower extremities compared with the subjects with AD[-DM]. Both female and male subjects with DrD had a significantly lower gait speed compared with the subjects with AD[-DM]. However, there were no significant differences in muscle mass and the prevalence of sarcopenia between the groups.

Conclusion: Subjects with DrD showed decreased muscle strength and quality, but not muscle mass, and had a low gait speed.

Keywords: Alzheimer disease; Dementia; Diabetes mellitus; Dynapenia; Muscle; Sarcopenia.

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