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. 2017 Aug 21;7(4):e12549.
doi: 10.5812/aapm.12549. eCollection 2017 Aug.

Effect of Remote Ischemic Preconditioning on Troponin I in CABG

Fatemeh Javaherforoosh Zadeh  1 , Mohsen Moadeli  2 , Mansoor Soltanzadeh  3 , Farahzad Janatmakan  2
Affiliations

Effect of Remote Ischemic Preconditioning on Troponin I in CABG

Fatemeh Javaherforoosh Zadeh et al. Anesth Pain Med. .

Abstract

Background: Elective open heart surgery is associated with troponin release in some cases due to myocyte necrosis.

Objectives: The aim of this study was to measure cardiac troponin I (cTnI) preoperatively in elective CABG after remote ischemic preconditioning.

Methods: Twenty-eight patients were selected for elective CABG. They were randomized to receive remote ischemic preconditioning (induced by three 5-min cycles of inflation with a pneumatic tourniquet and 5-min deflation between inflation episodes as reperfusion).

Outcomes: Primary outcomes were cardiac troponin I levels at 6 and 24 hours after the procedure, and the secondary outcomes included creatine phosphokinase, lactate dehydrogenase, and serum creatinine levels. Hemodynamic changes were evaluated between the treatment and control groups.

Results: Cardiac troponin I at 6 hours after preconditioning was significantly lower compared to the control group (P = 0.036), and after 24 hours, there was still a significant difference between the two groups (P < 0.05).

Conclusions: Remote ischemic preconditioning reduces ischemic biomarkers during coronary artery bypass graft and attenuates procedure-related cardiac troponin I release and eventually reduces cardiovascular events such as myocardial infarction, chest pain, and hemodynamic changes after cardiac surgery.

Keywords: Cardiac Outcomes; Cardiac Surgery; Remote Ischemic Preconditioning.

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