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. 2018 Feb;51(1):35-40.
doi: 10.5090/kjtcs.2018.51.1.35. Epub 2018 Feb 5.

Outcomes of the Multimodal Treatment of Malignant Pleural Mesiothelioma: The Role of Surgery

Bub-Se Na  1 , Ji Seong Kim  1 , Kwanyong Hyun  1 , In Kyu Park  1 , Chang Hyun Kang  1 , Young Tae Kim  1
Affiliations

Outcomes of the Multimodal Treatment of Malignant Pleural Mesiothelioma: The Role of Surgery

Bub-Se Na et al. Korean J Thorac Cardiovasc Surg. 2018 Feb.

Erratum in

Abstract

Background: The treatment of malignant pleural mesothelioma (MPM) is challenging, and multimodal treatment including surgery is recommended; however, the role of surgery is debated. The treatment outcomes of MPM in Korea have not been reported. We analyzed the outcomes of MPM in the context of multimodal treatment, including surgery.

Methods: The records of 29 patients with pathologically proven MPM from April 1998 to July 2015 were retrospectively reviewed. The treatment outcomes of the surgery and non-surgery groups were compared.

Results: The overall median survival time was 10.6 months, and the overall 3-year survival rate was 25%. No postoperative 30-day or in-hospital mortality occurred in the surgery group. Postoperative complications included tachyarrhythmia (n=4), pulmonary thromboembolism (n=1), pneumonia (n=1), chylothorax (n=1), and wound complications (n=3). The treatment outcomes between the surgery and non-surgery groups were not significantly different (3-year survival rate: 31.3% vs. 16.7%, respectively; p=0.47). In a subgroup analysis, there was no significant difference in the treatment outcomes between the extrapleural pneumonectomy group and the non-surgery group (3-year survival rate: 45.5% vs. 16.7%, respectively; p=0.23).

Conclusion: Multimodal treatment incorporating surgery did not show better outcomes than non-surgical treatment. A nationwide multicenter data registry and prospective randomized controlled studies are necessary to optimize the treatment of MPM.

Keywords: Mesothelioma; Prognosis; Surgery.

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Conflict of interest statement

Conflict of interest No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1
(A) The Kaplan-Meier survival curves of all MPM patients. (B) Kaplan-Meier survival curves comparing the surgery group and non-surgery group. MPM, malignant pleural mesothelioma.
Fig. 2
Fig. 2
Kaplan-Meier survival curves comparing the EPP group and the non-surgery group. EPP, extrapleural pneumonectomy.
See this image and copyright information in PMC

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