Comparative Study
Phase II trial of vindesine in patients with acute leukemia
- PMID: 294307
Item in Clipboard
Comparative Study
Phase II trial of vindesine in patients with acute leukemia
Cancer Treat Rep.
1979 Nov-Dec.
Abstract
Vindesine was administered to 18 patients with acute leukemia who had failed conventional chemotherapy. Each course of therapy consisted of an iv bolus infusion at a dose of 1-2 mg/m2 given daily x 5-10 days. Of 13 patients with acute lymphoblastic leukemia, two had partial remissions which lasted 2 and 3 months and five had minor responses. One of three patients with acute nonlymphoblastic leukemia and one of two patients with blastic crisis of chronic myelogenous leukemia each had a minor response. The data suggest that vindesine has activity in the treatment of acute leukemia.
Similar articles
-
[Leukaemias and lymphomas treatment by vindesine. Result of a phase II trial in terms of remission induction (author's transl)].Nouv Presse Med. 1978 Feb 18;7(7):525-8. Nouv Presse Med. 1978. PMID: 273888 French.
-
Phase II clinical trial with vindesine for remission induction in acute leukemia, blastic crisis of chronic myeloid leukemia, lymphosarcoma, and hodgkin's disease: absence of cross-resistance with vincristine.Cancer Treat Rep. 1978 May;62(5):805-9. Cancer Treat Rep. 1978. PMID: 274996
-
[Phase II study of vindesine in hematological malignancies].Gan To Kagaku Ryoho. 1983 Dec;10(12):2509-15. Gan To Kagaku Ryoho. 1983. PMID: 6580841 Japanese.
-
A phase I study of idarubicin hydrochloride in patients with acute leukemia. The Idarubicin Study Group of Japan.Semin Hematol. 1996 Oct;33(4 Suppl 3):2-11. Semin Hematol. 1996. PMID: 8916310 Review.
-
Vindesine: a new vinca alkaloid.Recent Results Cancer Res. 1980;74:91-7. doi: 10.1007/978-3-642-81488-4_13. Recent Results Cancer Res. 1980. PMID: 7003662 Review.
Cited by
-
Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.Cancer Chemother Pharmacol. 1983;10(3):224-6. doi: 10.1007/BF00255770. Cancer Chemother Pharmacol. 1983. PMID: 6345018 Clinical Trial.