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Comparative Study
. 1979 Nov-Dec;63(11-12):2063-5.

Phase II trial of vindesine in patients with acute leukemia

R B Sklaroff, Z Arlin, C W Young
  • PMID: 294307
Comparative Study

Phase II trial of vindesine in patients with acute leukemia

R B Sklaroff et al. Cancer Treat Rep. 1979 Nov-Dec.

Abstract

Vindesine was administered to 18 patients with acute leukemia who had failed conventional chemotherapy. Each course of therapy consisted of an iv bolus infusion at a dose of 1-2 mg/m2 given daily x 5-10 days. Of 13 patients with acute lymphoblastic leukemia, two had partial remissions which lasted 2 and 3 months and five had minor responses. One of three patients with acute nonlymphoblastic leukemia and one of two patients with blastic crisis of chronic myelogenous leukemia each had a minor response. The data suggest that vindesine has activity in the treatment of acute leukemia.

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