Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Feb;8(2):140-142.
doi: 10.1158/2159-8290.CD-17-1355.

ERK Inhibition: A New Front in the War against MAPK Pathway-Driven Cancers?

Inna Smalley  1 , Keiran S M Smalley  2   3
Affiliations
Comment

ERK Inhibition: A New Front in the War against MAPK Pathway-Driven Cancers?

Inna Smalley et al. Cancer Discov. 2018 Feb.

Abstract

<b/> ERK inhibitors have enormous therapeutic potential against tumors that are BRAF mutant, BRAF-MEK inhibitor resistant, or RAS mutant. In this issue of Cancer Discovery, Sullivan and colleagues report on the first-in-human dose-escalation study of the ERK inhibitor ulixertinib, which they show to be well tolerated with clinical activity against a wide range of tumor types. Cancer Discov; 8(2); 140-2. ©2018 AACR.See related article by Sullivan et al., p. 184.

PubMed Disclaimer

Comment on

Publication types