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. 2018 Feb 12;18(1):235.
doi: 10.1186/s12889-018-5131-4.

Strengthening health data on a rare and heterogeneous disease: sarcoma incidence and histological subtypes in Germany

Meike Ressing  1   2 , Eva Wardelmann  3 , Peter Hohenberger  4 , Jens Jakob  4 , Bernd Kasper  5 , Katharina Emrich  1   2 , Andrea Eberle  6 , Maria Blettner  2 , Sylke Ruth Zeissig  7   8
Affiliations

Strengthening health data on a rare and heterogeneous disease: sarcoma incidence and histological subtypes in Germany

Meike Ressing et al. BMC Public Health. .

Abstract

Background: The population-based incidence of sarcoma and its histological subtypes in Germany is unknown. Up-to-date information on a disease with an incidence comparable to other cancer entities is of high public health relevance. The aim of this study was to determine this incidence and to detect significant changes in incidence trends using data from German epidemiological cancer registries.

Methods: Pooled data from the German Centre for Cancer Registry Data with a primary diagnosis occurring in 2013 were used. To date, this is the latest data on cancer incidence available for Germany. All German cancer registries with sufficient completeness were included (10 out of 11), covering a population of 70.0 million people, representing 87% of the German population. All malignant sarcomas according to the RARECARE Project and the WHO classification 2002 were considered for analysis and, above all, gastrointestinal stromal tumours (GIST) of uncertain behaviour. Sensitivity analysis was performed excluding certain histologies.

Results: The analysis included 3404 cases in men and 3442 cases in women diagnosed in 2013. The age adjusted sarcoma incidence (European standard) was 7.4 (men) and 6.6 (women) per 100,000 inhabitants. About 70% of sarcomas were soft tissue sarcomas, about 22% GIST, and about 9% bone sarcomas. The most common histological subtypes besides GIST were fibrosarcomas (14%) and liposarcomas (12%) in men and complex mixed and stromal neoplasms (22%), non-uterine leiomysarcomas (10%) and fibrosarcomas (9%) in women. Considering the trend for the years of diagnosis 2004 to 2013, there was a significant increase in incidence for GIST while the incidence of soft tissue sarcomas (only men) as well as of bone sarcoma stayed constant over time. As to soft tissue sarcoma in women, the incidence stayed constant up to the year 2009 and significantly decreased afterwards.

Conclusion: This study is the first detailed analysis of a German-wide population-based sarcoma incidence showing results comparable to the incidence detected in the RARECARE Project.

Keywords: Gastrointestinal Stromal tumours; Germany; Histology; Incidence; Neoplasms; Sarcoma; Topography, Medical.

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Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Age-specific incidence of sarcomas (per 100,000, according to the European standard 1976), year of diagnosis 2013. a Men; b Women
Fig. 2
Fig. 2
Trends of incidence rates for sarcoma entities, 2004–2013*. a Men; bWomen. *per 100,000; age-standardized according to the European standard 1976, Hessen excluded, Nordrhein-Westfalen only Muenster region
See this image and copyright information in PMC

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