Immunology of the Uterine and Vaginal Mucosae

Jordan Z Zhou¹, Sing Sing Way², Kang Chen³

Affiliations

¹ Departments of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA.
² Division of Infectious Disease, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA; Perinatal Institute, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
³ Departments of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA; Jiangsu Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China; Mucosal Immunology Studies Team, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kang@wayne.edu.

PMID: 29433961
DOI: 10.1016/j.it.2018.01.007

Review

Immunology of the Uterine and Vaginal Mucosae

Jordan Z Zhou et al. Trends Immunol. 2018 Apr.

. 2018 Apr;39(4):302-314.

doi: 10.1016/j.it.2018.01.007. Epub 2018 Feb 9.

Authors

Jordan Z Zhou¹, Sing Sing Way², Kang Chen³

Affiliations

¹ Departments of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA; Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA.
² Division of Infectious Disease, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA; Perinatal Institute, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
³ Departments of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA; Perinatology Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Detroit, MI 48201, USA; Jiangsu Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China; Mucosal Immunology Studies Team, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kang@wayne.edu.

PMID: 29433961
DOI: 10.1016/j.it.2018.01.007

Erratum in

Immunology of Uterine and Vaginal Mucosae: (Trends in Immunology 39, 302-314, 2018).
Zhou JZ, Way SS, Chen K. Zhou JZ, et al. Trends Immunol. 2018 Apr;39(4):355. doi: 10.1016/j.it.2018.02.006. Epub 2018 Mar 9. Trends Immunol. 2018. PMID: 29530651 Free PMC article.

Abstract

Along with the maintenance of symbiotic mutualism with commensal microbes and protection against invasive infections common to all mucosal barrier tissues, female reproductive tissues have additional, unique tasks that include dynamic cyclic cellular turnover in menstruation and immunological tolerance to genetically foreign fetal antigens in pregnancy. Here we review current knowledge on distinct features of the immune cells in female reproductive tissue with regard to antimicrobial host defense and adaptations to accommodate the fetus during pregnancy. Outstanding areas for future research to obtain new functional insights on this enigmatic mucosal barrier are also highlighted.

PubMed Disclaimer

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Immunology of the Uterine and Vaginal Mucosae

Affiliations

Immunology of the Uterine and Vaginal Mucosae

Authors

Affiliations

Erratum in

Abstract

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources