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. 2018 Feb;53(1):55-58.
doi: 10.1177/0018578717738079. Epub 2017 Nov 3.

Acute Hepatocellular Jaundice After Dofetilide Initiation: A Case Report

Patrick Gary Rose  1 , Robert Seabury  1 , Gregory Cwikla  1
Affiliations

Acute Hepatocellular Jaundice After Dofetilide Initiation: A Case Report

Patrick Gary Rose et al. Hosp Pharm. 2018 Feb.

Abstract

Dofetilide's hepatotoxicity is not well described. In this case report, we describe acute hepatocellular jaundice related to dofetilide use in a 33-year-old male being treated for atrial fibrillation. Both viral and ischemic causes of hepatocellular damage were ruled out as unlikely in this case. This case report outlines a rare yet probable report of idiosyncratic dofetilide-induced liver injury.

Keywords: adverse drug reactions; adverse drug reactions reporting/monitoring; cardiac agents; cardiovascular; gastrointestinal disorders.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Liver function tests and total bilirubin throughout hospital admission. Note. Hospital day 0 = day of admission; AST = aspartate aminotransferase; ALT = alanine aminotransferase; T. Bili = total bilirubin.
Figure 2.
Figure 2.
A timeline of patient events leading up to and throughout hospital admission. DC = Direct Current; ED = Emergency Department; INR = International Normalized Ratio; LFTs = Liver Function Tests; LLL = Left Lower Lobe.
See this image and copyright information in PMC

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