Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec 19;9(4):4607-4613.
doi: 10.18632/oncotarget.23461. eCollection 2018 Jan 12.

Prognostic factors for olfactory groove meningioma with nasal cavity extension

Ji Zhang #  1 , Ke Sai #  1 , Zheng-Quan Zhu #  2 , Fu Hua Lin #  1 , Zi-Feng Wang #  3 , Yong-Ming Chen #  4 , Chun-Yu Huang #  5 , Yun-Lin Ye #  6 , Xiao-Li Wang #  7 , You-Ping Li #  8 , Shu-Xin Sun #  1 , Wei-Ying Zhong #  9 , Jian-Bin Chen #  10 , Yun-Qiang Yang  11
Affiliations

Prognostic factors for olfactory groove meningioma with nasal cavity extension

Ji Zhang et al. Oncotarget. .

Abstract

Objectives: Meningioma recurrence remains a significant issue. No study has described the relationship between the clinical features and prognosis of communicating meningioma that primarily originates from the olfactory groove. The aim of the study was to identify prognostic factors of communicating olfactory groove meningiomas that could be stratified according to their risk of recurrence.

Results: A Simpson grade one or two resection was achieved. Complications with cerebrospinal rhinorrhoea occurred in two patients: one required reoperation, and the other was managed successfully with external drainage of lumbar cistern. There were 5 known clinical recurrences within the median follow-up of more than 5 years. The median 5-year recurrence-free survival for patients was 88.4%. Factors such as gender, tumour size, T2 signal and the hyperostotic bone had no significant effect on recurrence-free survival. However, recurrence was activated by oedema range, hyperostosis, dural tail sign and tumor texture (p < 0.05). Interestingly, female patients with the disease were younger than males at diagnosis, and the difference was statistically significant ( p = 0.013).

Conclusions: Based on these features of communicating olfactory groove meningiomas, different strategies may be adopted for the follow-up and subsequent treatment. Due to the relatively uncommon incidence, more investigations into the clinical behaviour of this entity are crucial.

Patients and methods: A retrospective study of 43 patients harbouring olfactory groove meningiomas invading the ethmoid or nasal cavity was conducted at three medical centers from 2000 to 2010. The records were reviewed for clinical presentations, imaging studies, surgical observation, histological features and follow-up.

Keywords: communicating; olfactory groove meningioma; prognosis factors; recurrence.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that we have no competing interests.

Figures

Figure 1
Figure 1. Kaplan–Meier representation of recurrence free survival over five years for all cases with communicating OGM
Figure 2
Figure 2. Survival in recurrent and non-recurrent cases
Figure 3
Figure 3. Cranial MR image displaying olfactory groove tumor with nasal cavity extension and follow-up with no recurrence
See this image and copyright information in PMC

References

    1. Saraf S, McCarthy BJ, Villano JL. Update on meningiomas. Oncologist. 2011;16:1604–13. https://doi.org/10.1634/theoncologist.2011-0193 - DOI - PMC - PubMed
    1. Yew A, Trang A, Nagasawa DT, Spasic M, Choy W, Garcia HM, Yang I. Chromosomal alterations, prognostic factors, and targeted molecular therapies for malignant meningiomas. J Clin Neurosci. 2013;20:17–22. https://doi.org/10.1016/j.jocn.2012.02.007 - DOI - PubMed
    1. Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, et al. Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. JAMA. 2006;295:2483–91. https://doi.org/10.1001/jama.295.21.2483 - DOI - PubMed
    1. Maillo A, Orfao A, Espinosa AB, Sayagues JM, Merino M, Sousa P, Lara M, Tabernero MD. Early recurrences in histologically benign/grade I meningiomas are associated with large tumors and coexistence of monosomy 14 and del(1p36) in the ancestral tumor cell clone. Neuro Oncol. 2007;9:438–46. https://doi.org/10.1215/15228517-2007-026 - DOI - PMC - PubMed
    1. Ildan F, Erman T, Gocer AI, Tuna M, Bagdatoglu H, Cetinalp E, Burgut R. Predicting the probability of meningioma recurrence in the preoperative and early postoperative period: a multivariate analysis in the midterm follow-up. Skull Base. 2007;17:157–71. https://doi.org/10.1055/s-2007-970554 - DOI - PMC - PubMed

LinkOut - more resources