Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Mar 29;9(4):5473-5479.
doi: 10.18632/oncotarget.16681. eCollection 2018 Jan 12.

miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis

Tiantian Wang  1 , Hao Xu  1 , Ming Qi  1 , Sheng Yan  2 , Xingsong Tian  1
Affiliations
Review

miRNA dysregulation and the risk of metastasis and invasion in papillary thyroid cancer: a systematic review and meta-analysis

Tiantian Wang et al. Oncotarget. .

Abstract

Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for "invasion", "thyroid cancer", and "miRNA". This revealed 29 dysregulated miRNAs associated with TC in 16 articles; the presence of invasion was confirmed in each respective article by laboratory research or patient follow-up. Among these miRNAs, miRNA-146b, miRNA-221, and miRNA-222 were analyzed further due to their higher frequencies across multiple studies. Of these studies, 6 were included in the meta-analysis, as they compared invasive PTC with paired normal tissues or non-invasive PTC.

Keywords: invasive thyroid cancer; meta-analysis; metastasis; miRNA.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST The author declares no conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart of search strategy
Figure 2
Figure 2. Quality of selected studies according to QUADAS-2 guidelines
Figure 3
Figure 3. Forest plots for miRNA-146, miRNA-221, and miRNA-222 in the described articles
As I2 > 50%, a random-effects model was used. p < 0.05, indicated that miRNA-146, miRNA-221, and miRNA-222 were all upregulated in invasive tumors compared with paired controls.
Figure 4
Figure 4. Funnel plot to measure publication bias, with regards to miRNA-146
Due to the relative lack of research studies, publication bias is somewhat unavoidable.
Figure 4
Figure 4. Funnel plot to measure publication bias, with regards to miRNA-146
Due to the relative lack of research studies, publication bias is somewhat unavoidable.
See this image and copyright information in PMC

References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. doi: 10.3322/caac.21262. - DOI - PubMed
    1. Xing M, Alzahrani AS, Carson KA, Shong YK, Kim TY, Viola D, Elisei R, Bendlova B, Yip L, Mian C, Vianello F, Tuttle RM, Robenshtok E, et al. Association between BRAF V600E mutation and recurrence of papillary thyroid cancer. J Clin Oncol. 2015;33:42–50. doi: 10.1200/JCO.2014.56.8253. - DOI - PMC - PubMed
    1. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 2001;294:853–8. doi: 10.1126/science.1064921. - DOI - PubMed
    1. Mraz M, Malinova K, Mayer J, Pospisilova S. MicroRNA isolation and stability in stored RNA samples. Biochem Biophys Res Commun. 2009;390:1–4. doi: 10.1016/j.bbrc.2009.09.061. - DOI - PubMed
    1. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008;105:10513–8. doi: 10.1073/pnas.0804549105. - DOI - PMC - PubMed

LinkOut - more resources