The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Osamu Nishida¹, Hiroshi Ogura², Moritoki Egi³, Seitaro Fujishima⁴, Yoshiro Hayashi⁵, Toshiaki Iba⁶, Hitoshi Imaizumi⁷, Shigeaki Inoue⁸, Yasuyuki Kakihana⁹, Joji Kotani¹⁰, Shigeki Kushimoto¹¹, Yoshiki Masuda¹², Naoyuki Matsuda¹³, Asako Matsushima¹⁴, Taka-Aki Nakada¹⁵, Satoshi Nakagawa¹⁶, Shin Nunomiya¹⁷, Tomohito Sadahiro¹⁸, Nobuaki Shime¹⁹, Tomoaki Yatabe²⁰, Yoshitaka Hara¹, Kei Hayashida²¹, Yutaka Kondo²², Yuka Sumi²³, Hideto Yasuda⁵, Kazuyoshi Aoyama^{24

25}, Takeo Azuhata²⁶, Kent Doi²⁷, Matsuyuki Doi²⁸, Naoyuki Fujimura²⁹, Ryota Fuke³⁰, Tatsuma Fukuda³¹, Koji Goto³², Ryuichi Hasegawa³³, Satoru Hashimoto³⁴, Junji Hatakeyama³⁵, Mineji Hayakawa³⁶, Toru Hifumi³⁷, Naoki Higashibeppu³⁸, Katsuki Hirai³⁹, Tomoya Hirose⁴⁰, Kentaro Ide¹⁶, Yasuo Kaizuka⁴¹, Tomomichi Kan'o⁴², Tatsuya Kawasaki⁴³, Hiromitsu Kuroda⁴⁴, Akihisa Matsuda⁴⁵, Shotaro Matsumoto¹⁶, Masaharu Nagae³, Mutsuo Onodera⁴⁶, Tetsu Ohnuma⁴⁷, Kiyohiro Oshima⁴⁸, Nobuyuki Saito⁴⁹, So Sakamoto⁵⁰, Masaaki Sakuraya⁵¹, Mikio Sasano⁵², Norio Sato⁵³, Atsushi Sawamura⁵⁴, Kentaro Shimizu², Kunihiro Shirai⁵⁵, Tetsuhiro Takei⁵⁶, Muneyuki Takeuchi⁵⁷, Kohei Takimoto⁵⁸, Takumi Taniguchi⁵⁹, Hiroomi Tatsumi¹², Ryosuke Tsuruta⁶⁰, Naoya Yama⁶¹, Kazuma Yamakawa⁶², Chizuru Yamashita¹, Kazuto Yamashita⁶³, Takeshi Yoshida⁶⁴, Hiroshi Tanaka⁶, Shigeto Oda¹⁵

Affiliations

¹ 1Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192 Japan.
² 2Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
³ 3Department of anesthesiology, Kobe University Hospital, Kobe, Japan.
⁴ 4Center for General Medicine Education, Keio University School of Medicine, Tokyo, Japan.
⁵ 5Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
⁶ 6Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁷ 7Department of Anesthesiology and Critical Care Medicine, Tokyo Medical University School of Medicine, Tokyo, Japan.
⁸ 8Department of Emergency and Critical Care Medicine, Tokai University Hachioji Hospital, Tokyo, Japan.
⁹ 9Department of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
¹⁰ 10Department of Disaster and Emergency Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
¹¹ 11Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
¹² 12Department of Intensive Care Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
¹³ 13Department of Emergency & Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
¹⁴ 14Department of Advancing Acute Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
¹⁵ 15Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
¹⁶ 16Division of Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan.
¹⁷ 17Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.
¹⁸ 18Department of Emergency and Critical Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Tokyo, Japan.
¹⁹ 19Department of Emergency and Critical Care Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Higashihiroshima, Japan.
²⁰ Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kochi, Japan.
²¹ 21Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan.
²² 22Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
²³ Healthcare New Frontier Promotion Headquarters Office, Kanagawa Prefectural Government, Yokohama, Japan.
²⁴ 24Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada.
²⁵ 25Department of Anesthesia, Faculty of Medicine, University of Toronto, Toronto, Canada.
²⁶ 26Division of Emergency and Critical Care Medicine, Departmen of Acute Medicine, Nihon university school of Medicine, Tokyo, Japan.
²⁷ 27Department of Acute Medicine, The University of Tokyo, Tokyo, Japan.
²⁸ 28Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Japan.
²⁹ 29Department of Anesthesiology, St. Mary's Hospital, Westminster, UK.
³⁰ 30Division of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
³¹ 31Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
³² 32Department of Anesthesiology and Intensive Care, Faculty of Medicine, Oita University, Oita, Japan.
³³ 33Department of Emergency and Intensive Care Medicine, Mito Clinical Education and Training Center, Tsukuba University Hospital, Mito Kyodo General Hospital, Mito, Japan.
³⁴ 34Department of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine, Tsukuba, Japan.
³⁵ Department of Intensive Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
³⁶ 36Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan.
³⁷ 37Emergency Medical Center, Kagawa University Hospital, Miki, Japan.
³⁸ Department of Anesthesia and Critical Care, Kobe City Medical Center General Hospital, Kobe City Hospital Organization, Kobe, Japan.
³⁹ 39Department of Pediatrics, Kumamoto Red cross Hospital, Kumamoto, Japan.
⁴⁰ 40Emergency and Critical Care Medical Center, Osaka Police Hospital, Osaka, Japan.
⁴¹ Department of Emergency & ICU, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
⁴² 42Department of Emergency & Critical Care Medicine Kitasato University, Tokyo, Japan.
⁴³ 43Department of Pediatric Critical Care, Shizuoka Children's Hospital, Shizuoka, Japan.
⁴⁴ 44Department of Anesthesia, Obihiro Kosei Hospital, Obihiro, Japan.
⁴⁵ 45Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
⁴⁶ 46Department of Emergency and Critical Care Medicine, Tokushima University Hospital, Tokushima, Japan.
⁴⁷ 47Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA.
⁴⁸ 48Department of Emergency Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
⁴⁹ 49Shock and Trauma Center, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
⁵⁰ 50Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo, Japan.
⁵¹ 51Department of Emergency and Intensive Care Medicine, JA Hiroshima General Hospital, Hatsukaichi, Japan.
⁵² Department of Intensive Care Medicine, Nakagami Hospital, Uruma, Japan.
⁵³ 53Department of Aeromedical Services for Emergency and Trauma Care, Ehime University Graduate School of Medicine, Matsuyama, Japan.
⁵⁴ 54Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
⁵⁵ 55Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
⁵⁶ Department of Emergency and Critical Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
⁵⁷ Department of Intensive Care Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.
⁵⁸ 58Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
⁵⁹ 59Department of Anesthesiology and Intensive Care Medicine, Kanazawa University, Kanazawa, Japan.
⁶⁰ 60Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Japan.
⁶¹ 61Department of Diagnostic Radiology, Sapporo Medical University School of Medicine, Sapporo, Japan.
⁶² Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.
⁶³ 63Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
⁶⁴ 64Intensive Care Unit, Osaka University Hospital, Osaka, Japan.

PMID: 29435330
PMCID: PMC5797365
DOI: 10.1186/s40560-017-0270-8

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Osamu Nishida et al. J Intensive Care. 2018.

. 2018 Feb 2:6:7.

doi: 10.1186/s40560-017-0270-8. eCollection 2018.

Authors

Affiliations

¹ 1Department of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192 Japan.
² 2Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Suita, Japan.
³ 3Department of anesthesiology, Kobe University Hospital, Kobe, Japan.
⁴ 4Center for General Medicine Education, Keio University School of Medicine, Tokyo, Japan.
⁵ 5Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
⁶ 6Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
⁷ 7Department of Anesthesiology and Critical Care Medicine, Tokyo Medical University School of Medicine, Tokyo, Japan.
⁸ 8Department of Emergency and Critical Care Medicine, Tokai University Hachioji Hospital, Tokyo, Japan.
⁹ 9Department of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
¹⁰ 10Department of Disaster and Emergency Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
¹¹ 11Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
¹² 12Department of Intensive Care Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.
¹³ 13Department of Emergency & Critical Care Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
¹⁴ 14Department of Advancing Acute Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
¹⁵ 15Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
¹⁶ 16Division of Critical Care Medicine, National Center for Child Health and Development, Tokyo, Japan.
¹⁷ 17Division of Intensive Care, Department of Anesthesiology and Intensive Care Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.
¹⁸ 18Department of Emergency and Critical Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Tokyo, Japan.
¹⁹ 19Department of Emergency and Critical Care Medicine, Institute of Biomedical & Health Sciences, Hiroshima University, Higashihiroshima, Japan.
²⁰ Department of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Kochi, Japan.
²¹ 21Department of Emergency and Critical Care Medicine, School of Medicine, Keio University, Tokyo, Japan.
²² 22Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
²³ Healthcare New Frontier Promotion Headquarters Office, Kanagawa Prefectural Government, Yokohama, Japan.
²⁴ 24Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada.
²⁵ 25Department of Anesthesia, Faculty of Medicine, University of Toronto, Toronto, Canada.
²⁶ 26Division of Emergency and Critical Care Medicine, Departmen of Acute Medicine, Nihon university school of Medicine, Tokyo, Japan.
²⁷ 27Department of Acute Medicine, The University of Tokyo, Tokyo, Japan.
²⁸ 28Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Hamamatsu, Japan.
²⁹ 29Department of Anesthesiology, St. Mary's Hospital, Westminster, UK.
³⁰ 30Division of Infectious Diseases and Infection Control, Tohoku Medical and Pharmaceutical University Hospital, Sendai, Japan.
³¹ 31Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
³² 32Department of Anesthesiology and Intensive Care, Faculty of Medicine, Oita University, Oita, Japan.
³³ 33Department of Emergency and Intensive Care Medicine, Mito Clinical Education and Training Center, Tsukuba University Hospital, Mito Kyodo General Hospital, Mito, Japan.
³⁴ 34Department of Anesthesiology and Intensive Care Medicine, Kyoto Prefectural University of Medicine, Tsukuba, Japan.
³⁵ Department of Intensive Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
³⁶ 36Emergency and Critical Care Center, Hokkaido University Hospital, Sapporo, Japan.
³⁷ 37Emergency Medical Center, Kagawa University Hospital, Miki, Japan.
³⁸ Department of Anesthesia and Critical Care, Kobe City Medical Center General Hospital, Kobe City Hospital Organization, Kobe, Japan.
³⁹ 39Department of Pediatrics, Kumamoto Red cross Hospital, Kumamoto, Japan.
⁴⁰ 40Emergency and Critical Care Medical Center, Osaka Police Hospital, Osaka, Japan.
⁴¹ Department of Emergency & ICU, Steel Memorial Yawata Hospital, Kitakyushu, Japan.
⁴² 42Department of Emergency & Critical Care Medicine Kitasato University, Tokyo, Japan.
⁴³ 43Department of Pediatric Critical Care, Shizuoka Children's Hospital, Shizuoka, Japan.
⁴⁴ 44Department of Anesthesia, Obihiro Kosei Hospital, Obihiro, Japan.
⁴⁵ 45Department of Surgery, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
⁴⁶ 46Department of Emergency and Critical Care Medicine, Tokushima University Hospital, Tokushima, Japan.
⁴⁷ 47Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, USA.
⁴⁸ 48Department of Emergency Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.
⁴⁹ 49Shock and Trauma Center, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
⁵⁰ 50Department of Emergency and Critical Care Medicine, Juntendo University Nerima Hospital, Tokyo, Japan.
⁵¹ 51Department of Emergency and Intensive Care Medicine, JA Hiroshima General Hospital, Hatsukaichi, Japan.
⁵² Department of Intensive Care Medicine, Nakagami Hospital, Uruma, Japan.
⁵³ 53Department of Aeromedical Services for Emergency and Trauma Care, Ehime University Graduate School of Medicine, Matsuyama, Japan.
⁵⁴ 54Division of Acute and Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
⁵⁵ 55Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
⁵⁶ Department of Emergency and Critical Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
⁵⁷ Department of Intensive Care Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.
⁵⁸ 58Department of Intensive Care Medicine, Kameda Medical Center, Kamogawa, Japan.
⁵⁹ 59Department of Anesthesiology and Intensive Care Medicine, Kanazawa University, Kanazawa, Japan.
⁶⁰ 60Advanced Medical Emergency and Critical Care Center, Yamaguchi University Hospital, Ube, Japan.
⁶¹ 61Department of Diagnostic Radiology, Sapporo Medical University School of Medicine, Sapporo, Japan.
⁶² Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.
⁶³ 63Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
⁶⁴ 64Intensive Care Unit, Osaka University Hospital, Osaka, Japan.

PMID: 29435330
PMCID: PMC5797365
DOI: 10.1186/s40560-017-0270-8

Abstract

Background and purpose: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016), a Japanese-specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 and published in the Journal of JSICM, [2017; Volume 24 (supplement 2)] 10.3918/jsicm.24S0001 and Journal of Japanese Association for Acute Medicine [2017; Volume 28, (supplement 1)] http://onlinelibrary.wiley.com/doi/10.1002/jja2.2017.28.issue-S1/issuetoc.This abridged English edition of the J-SSCG 2016 was produced with permission from the Japanese Association of Acute Medicine and the Japanese Society for Intensive Care Medicine.

Methods: Members of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ) and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two-thirds (> 66.6%) majority vote of each of the 19 committee members.

Results: A total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J-SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation, and its supporting evidence were also added to each recommendation statement. We conducted meta-analyses for 29 CQs. Thirty-seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for five CQs.

Conclusions: Based on the evidence gathered, we were able to formulate Japanese-specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non-specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

Keywords: Evidence-based medicine; Guidelines; Medical Information Network Distribution Service (Minds); Sepsis; Septic shock; Systematic review.

PubMed Disclaimer

Conflict of interest statement

Not applicable.Not applicable.All committee members and working group members submitted disclosure forms of financial and academic conflict of interest (COI) prior to being requested to participate in individual activities. All COI were collected according to the guideline by Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. Detailed information of COI and the roles in creating this clinical guideline are summarized in the Additional file 1.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

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The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Affiliations

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Authors

Affiliations

Abstract

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources

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