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Comment
. 2017 Sep 15;4(4):346-349.
doi: 10.1080/23328940.2017.1341968. eCollection 2017.

The IKD current in cold detection and pathological cold pain

María Pertusa  1 , Rodolfo Madrid  1
Affiliations
Comment

The IKD current in cold detection and pathological cold pain

María Pertusa et al. Temperature (Austin). .
No abstract available

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Figures

Figure 1.
Figure 1.
Thermal sensitivity of primary sensory neurons and damage-gated cold pain. These illustrations depict our proposal of the cold detection mechanisms operating in primary sensory neurons under physiological conditions (left) and after nerve injury (right). Scales on the peripheral endings depict the counterbalance of the functional expression of excitatory (TRPM8, blue) and brake (Kv1.1-1.2, red) channels involved in the fine tuning of cold detection in three functional subtypes of primary sensory neurons. The temperature at which these neurons would be excited is depicted by the colored thermometers at left of each panel. Note that the temperature values are an estimation of the temperature reached at the nerve endings. The size of the schematic channels reflects their relative functional contribution in the different subclasses of primary sensory neurons. Note that the functional expression level of TRPM8 remains unaltered in this model. LT-CSNs: Low threshold cold-sensitive neurons; HT-CSNs: High threshold cold-sensitive neurons; Recruitable Nociceptor: Nociceptive neurons that can be transformed into cold-sensitive neurons by the damage-gated downregulation of IKD.
See this image and copyright information in PMC

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