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Editorial
. 2018 May 1;75(5):536-538.
doi: 10.1001/jamaneurol.2017.4026.

Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture

Eric McDade  1 , Randall J Bateman  1
Affiliations
Editorial

Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture

Eric McDade et al. JAMA Neurol. .
No abstract available

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Figures

Figure 1
Figure 1
Aß and Tau biomarker trajectories in autosomal dominant AD. Approximate trajectories of amyloid beta (CSF and PET) and tau (CSF and PET) from cross-sectional studies in the DIAN and the E280A Colombian kindred. Based on prior studies and the current study by Quiroz et al., there is evidence of a period of approximately 10 to 15 years between the increase in soluble tau and neurofibrillary tangle pathology in the presymptomatic period.
See this image and copyright information in PMC

Dataset described in

References

    1. Braak H, Braak E. Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiology of aging. 1995;16(3):271–8. discussion 8–84. Epub 1995/05/01. PubMed PMID: 7566337. - PubMed
    1. Brier MR, Gordon B, Friedrichsen K, McCarthy J, Stern A, Christensen J, Owen C, Aldea P, Su Y, Hassenstab J, Cairns NJ, Holtzman DM, Fagan AM, Morris JC, Benzinger TL, Ances BM. Tau and Abeta imaging, CSF measures, and cognition in Alzheimer's disease. Science translational medicine. 2016;8(338):338ra66. doi: 10.1126/scitranslmed.aaf2362. Epub 2016/05/14. PubMed PMID: 27169802; PMCID: PMC5267531. - DOI - PMC - PubMed
    1. Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. 2016;87(9):920–6. doi: 10.1212/wnl.0000000000003050. Epub 2016/07/31. PubMed PMID: 27473132; PMCID: PMC5035159. - DOI - PMC - PubMed
    1. Ossenkoppele R, Schonhaut DR, Scholl M, Lockhart SN, Ayakta N, Baker SL, O'Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain : a journal of neurology. 2016;139(Pt 5):1551–67. doi: 10.1093/brain/aww027. Epub 2016/03/11. PubMed PMID: 26962052; PMCID: PMC5006248. - DOI - PMC - PubMed
    1. Pontecorvo MJ, Devous MD, Sr, Navitsky M, Lu M, Salloway S, Schaerf FW, Jennings D, Arora AK, McGeehan A, Lim NC, Xiong H, Joshi AD, Siderowf A, Mintun MA. Relationships between flortaucipir PET tau binding and amyloid burden, clinical diagnosis, age and cognition. Brain : a journal of neurology. 2017;140(3):748–63. doi: 10.1093/brain/aww334. Epub 2017/01/13. PubMed PMID: 28077397; PMCID: PMC5382945. - DOI - PMC - PubMed

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