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Review
. 2018 Apr 25;56(5):e00139-18.
doi: 10.1128/JCM.00139-18. Print 2018 May.

Impact of 21st Century Cures Act on Breakpoints and Commercial Antimicrobial Susceptibility Test Systems: Progress and Pitfalls

Romney M Humphries  1 , Mary Jane Ferraro  2 , Janet A Hindler  3
Affiliations
Review

Impact of 21st Century Cures Act on Breakpoints and Commercial Antimicrobial Susceptibility Test Systems: Progress and Pitfalls

Romney M Humphries et al. J Clin Microbiol. .

Abstract

Antimicrobial resistance is the most pressing medical challenge of the past decade. At the front line are clinical laboratories, which are responsible for accurately reporting antimicrobial susceptibility test (AST) results to clinicians and public health authorities. The ability of the laboratory to detect resistance has been hampered by several factors. In 2016, the 21st Century Cures Act was signed into law, marking an important step toward resolving many regulatory dilemmas that hampered development and updates to commercial AST systems (cASTs). We describe the pathway and history of U.S. regulation of cASTs and outline both the rewards and unmet needs possible from the 21st Century Cures Act.

Keywords: 21st Century Cures Act; Clinical and Laboratory Standards Institute; Food and Drug Administration; antimicrobial susceptibility testing; breakpoints.

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References

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