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. 1986 Aug;73(4):354-7.
doi: 10.1007/BF00279100.

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization

J E Landegent, N Jansen in de Wal, Y M Fisser-Groen, E Bakker, M van der Ploeg, P L Pearson

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization

J E Landegent et al. Hum Genet. 1986 Aug.

Abstract

The chromosomal localization of a unique DNA fragment, closely linked to Huntington disease (HD), was assessed in situ by hybridization with 2-acetylaminofluorene (AAF) modified probes. In these experiments, a cosmid cloned genomic fragment (c5.5) was used for hybridization. Here we present evidence that confirms the mapping of the D4S10 locus to the p16 region of chromosome 4 and assigns it to the telomere of the short arm.

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References

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