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Editorial
. 2018 Apr;71(4):559-560.
doi: 10.1161/HYPERTENSIONAHA.118.10773. Epub 2018 Feb 5.

Genetic Susceptibility to Hypertension-Induced Renal Injury

Richard J Roman  1 , Fan Fan  2
Affiliations
Editorial

Genetic Susceptibility to Hypertension-Induced Renal Injury

Richard J Roman et al. Hypertension. 2018 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Summary of the effects of transfer of regions of chromosomes 6 (SpSHR.6SHR) and 17 (SpSHR.17SHR) from Spontaneously Hypertensive Rats (SHR, SHR-B2 in Dhande et al.) to Stroke-prone SHR (SpSHR, SHR-A3 in Dhande et al.) on blood pressure and renal injury. Transfer of these regions lowered glomerular injury, renal interstitial fibrosis and urinary excretion of neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN) and kidney injury molecule 1 (KIM1), but had no effect on proteinuria. Blood pressure was reduced in the SpSHR.17SHR and SpSHR. 6SHR17SHR dual congenic rats but not SpSHR.6SHR. The fall in renal injury in the SpSHR.17SHR congenic strain might be due to the reduction of blood pressure back into the autoregulatory range and a reduction in glomerular capillary pressure (Pgc). The renoprotection afforded by chromosome 6 is likely due to variants in IgH genes that influence B cell and immune function.
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Comment on

References

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