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Comment
. 2018 Feb 12;33(2):153-155.
doi: 10.1016/j.ccell.2018.01.014.

Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery

Donald P McDonnell  1 , John D Norris  2 , Ching-Yi Chang  2
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Neomorphic ERα Mutations Drive Progression in Breast Cancer and Present a Challenge for New Drug Discovery

Donald P McDonnell et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Jeselsohn et al. dissect the function of several of the most clinically important estrogen receptor alpha mutants associated with endocrine therapy resistance in breast cancer and demonstrate that they manifest disease-relevant neomorphic activities that likely contribute to tumor pathogenesis.

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