Myelodysplastic Syndrome Splicing Factor Mutations Induce R-Loops
- PMID: 29439150
- DOI: 10.1158/2159-8290.CD-RW2018-025
Myelodysplastic Syndrome Splicing Factor Mutations Induce R-Loops
Abstract
Mutations in SRSF2 and U2AF35 trigger replication stress and ATR activation via R-loop formation.
©2018 American Association for Cancer Research.
Comment on
-
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.Mol Cell. 2018 Feb 1;69(3):412-425.e6. doi: 10.1016/j.molcel.2017.12.029. Epub 2018 Jan 27. Mol Cell. 2018. PMID: 29395063 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
