MYCN Amplification Promotes Enhancer Invasion in Neuroblastoma
- PMID: 29439151
- DOI: 10.1158/2159-8290.CD-RW2018-023
MYCN Amplification Promotes Enhancer Invasion in Neuroblastoma
Abstract
Excess MYCN binds noncanonical enhancers as well as promoters to drive tumor-specific gene expression.
©2018 American Association for Cancer Research.
Comment on
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Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.Nat Genet. 2018 Apr;50(4):515-523. doi: 10.1038/s41588-018-0044-9. Epub 2018 Jan 29. Nat Genet. 2018. PMID: 29379199 Free PMC article.
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