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Review
. 2018 Feb 11;7(2):29.
doi: 10.3390/jcm7020029.

A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents

Stephanie A Joppa  1 , Justin Salciccioli  2 , Jill Adamski  3 , Salma Patel  4 , Waldemar Wysokinski  5 , Robert McBane  6 , Farah Al-Saffar  7 , Heidi Esser  8 , Fadi Shamoun  9
Affiliations
Review

A Practical Review of the Emerging Direct Anticoagulants, Laboratory Monitoring, and Reversal Agents

Stephanie A Joppa et al. J Clin Med. .

Abstract

Millions of patients in the United States use anticoagulation for a variety of indications, such as the prevention of stroke in those with atrial fibrillation (AF) and the treatment and prevention of venous thrombosis. For over six decades warfarin was the only available oral anticoagulant, but now several DOACs are available and their use has become more prevalent in recent years. In spite of this increased use, many physicians remain reluctant to prescribe DOACs due to concerns about bleeding and reversibility.

Keywords: anticoagulants; reversal agents; serum levels.

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Conflict of interest statement

The authors declare no conflict of interest.

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