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Comment
. 2018 May 15;24(10):2239-2240.
doi: 10.1158/1078-0432.CCR-18-0183. Epub 2018 Feb 12.

Surrogate and Intermediate Endpoints in Randomized Trials: What's the Goal?

Edward L Korn  1 , Boris Freidlin  2
Affiliations
Comment

Surrogate and Intermediate Endpoints in Randomized Trials: What's the Goal?

Edward L Korn et al. Clin Cancer Res. .

Abstract

Establishing trial-level surrogacy of an intermediate endpoint for predicting survival benefit in future trials is extremely challenging because of the extrapolations required, but there are other useful drug development and patient management applications of intermediate endpoints. Clin Cancer Res; 24(10); 2239-40. ©2018 AACRSee related article by Mushti et al., p. 2268.

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