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Comment
. 2018 Mar 5;215(3):723-724.
doi: 10.1084/jem.20180241. Epub 2018 Feb 12.

Defusing inflammasomes

Andrew Sandstrom  1 , Russell E Vance  2
Affiliations
Comment

Defusing inflammasomes

Andrew Sandstrom et al. J Exp Med. .

Abstract

In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.

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Figures

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Insight from Andrew Sandstrom and Russell E. Vance
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Pathway of caspase-1 activation and inactivation by autolytic cleavage. Caspase-1 (blue) is recruited to the ASC speck (gray). Dimerization of caspase-1 leads to limited activity (as indicated in yellow) and autolytic cleavage of the interdomain linker between the p20 and p10 subunits. The processed p33/p10 dimer complex is fully active (as indicated in red); however, further processing of the CARD domain linker leads to dissociation of caspase-1 from the ASC speck and inactivity because of low concentration.
See this image and copyright information in PMC

Comment on

References

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