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Comment
. 2018 Feb 27;115(9):E1942-E1943.
doi: 10.1073/pnas.1722131115. Epub 2018 Feb 9.

Melatonin signaling in mitochondria extends beyond neurons and neuroprotection: Implications for angiogenesis and cardio/gastroprotection

Amrita Ahluwalia  1 , Iwona M Brzozowska  2 , Neil Hoa  1 , Michael K Jones  1   3 , Andrzej S Tarnawski  4   3
Affiliations
Comment

Melatonin signaling in mitochondria extends beyond neurons and neuroprotection: Implications for angiogenesis and cardio/gastroprotection

Amrita Ahluwalia et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Localization of melatonin receptors MT1 and MT2 in MM of gastric endothelial cells (GECs). (A) Staining of mitochondria using MitoTracker, a fluorescent dye that stains mitochondria (red) in a manner dependent on mitochondrial membrane potential. (B) Immunofluorescence staining for MT1 in GECs (green). (C) Overlay of MitoTracker and MT1 immunostaining images showing localization of MT1 in MM as yellow/orange staining (arrows). (D) Staining of mitochondria using MitoTracker (red). (E) Immunofluorescence staining for MT2 in GECs (green); please note strong MT2 expression in the nucleus (N). (F) Overlay of MitoTracker and MT2 immunostaining images showing localization of MT2 in MM as yellow/orange staining (arrows).
See this image and copyright information in PMC

Comment in

Comment on

  • Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
    Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM. Suofu Y, et al. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5. Proc Natl Acad Sci U S A. 2017. PMID: 28874589 Free PMC article.

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