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. 2018 Feb 14:24:912-918.
doi: 10.12659/msm.905789.

The Genotype of Human Papillomavirus and Associated Factors Among High Risk Males in Shanghai, China: A Molecular Epidemiology Study

Chengzhong Zhang  1   2 , Chao Zhang  1   3 , Jie Huang  1 , Weimin Shi  4
Affiliations

The Genotype of Human Papillomavirus and Associated Factors Among High Risk Males in Shanghai, China: A Molecular Epidemiology Study

Chengzhong Zhang et al. Med Sci Monit. .

Abstract

BACKGROUND The aim of this study was to describe the infection rate of human papillomavirus (HPV), its genotype distribution, and associated factors among high-risk males in Shanghai, China. MATERIAL AND METHODS A total of 1,205 participants were enrolled in this study from October 2015 to March 2017. Each individual signed an informed consent before agreeing to take part in this study; participants completed a questionnaire about associated factors related to HPV infection. The HPV GenoArray test kit was used to perform HPV genotyping and was also used in DNA amplification and HybriBio's proprietary flow-through hybridization technique. RESULTS The overall infection rate of HPV was 58.4%. HPV 11 (177, 14%) was the most common low-risk (LR) genotype and HPV 16 (78, 6.47%) was the top prevalent high-risk (HR) genotype among all the male patients. Additionally, multiple infections (387, 32.1%) was the most common type among all the infected cases, while single infection was only 317 cases (26.3%). Sexual preference, number of sex partners, sexual activity, and frequency of condom use were significantly associated with HR and LR infection. CONCLUSIONS The infection rate of HPV infection among high-risk males in Shanghai was very high.

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Figures

Figure 1
Figure 1
Distribution of HPV genotypes among sample: (A) infection rate of HR HPV among samples; (B) infection rate of LR HPV among samples.
Figure 2
Figure 2
Infection rate and of HPV among samples grouped by age.
See this image and copyright information in PMC

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