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. 2017 May-Jun;21(3):210-215.
doi: 10.4103/jisp.jisp_157_17.

Effectiveness of erythrosine-mediated photodynamic antimicrobial chemotherapy on dental plaque aerobic microorganisms: A randomized controlled trial

Manohar Bhat  1 , Swathi Acharya  2 , Kakarla Veera Venkata Prasad  3 , Raghavendra Kulkarni  4 , Anithraj Bhat  5 , Devikripa Bhat  6
Affiliations

Effectiveness of erythrosine-mediated photodynamic antimicrobial chemotherapy on dental plaque aerobic microorganisms: A randomized controlled trial

Manohar Bhat et al. J Indian Soc Periodontol. 2017 May-Jun.

Abstract

Background: Dental plaque is one of the predominant causes of major oral diseases. Although mechanical and chemical methods are extensively followed to control the development of plaque, plaque-related diseases still persist. Therefore, this necessitates for alternative measures of plaque control, one such alternative is photodynamic antimicrobial chemotherapy (PACT).

Materials and methods: Split mouth randomized clinical trial (CTRI/2017/03/008239) was conducted on 30 participants who reported to the hospital. Participants were asked to rinse their mouth for 1 min using 10 ml of 25 μM erythrosine solutions. Same tooth on both quadrants of the same jaw are selected as the test and control. Intervention used was halogen-based composite curing light with wavelength of 500-590 nm. Plaque sample from the control tooth and test tooth was collected before and after exposure, respectively, and sent to microbiological laboratory for colony count.

Results: Logarithmic mean and standard deviation of control group with 102 dilutions of aerobic microbial count were found to be 5.34 ± 0.94, and for experimental group, it was 4.47 ± 1.37. The statistical difference between mean CFU values between aerobic bacterial counts was significant (P = 0.006).

Conclusions: Erythrosine-mediated PACT reduces the extent of dental plaque microbial count and has a potential preventive and therapeutic use in day-to-day life and dental clinics.

Keywords: Dental plaque; erythrosine; photodynamic antimicrobial chemotherapy.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart
Figure 2
Figure 2
Quantification of plaque using plaque index
Figure 3
Figure 3
Application of light to experimental area using halogen-based composite curing light
Figure 4
Figure 4
Microbiological colony counting using digital colony counter
Figure 5
Figure 5
Logarithmic mean of aerobic colony count in control group and plaque treated with the erythrosine and halogen-based composite curing light (experimental)
See this image and copyright information in PMC

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