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Review
. 2018;91(1):7-11.
doi: 10.15386/cjmed-807. Epub 2018 Jan 15.

Molecular epidemiology of the community-associated methicillin-resistant staphylococcus aureus clones: a synthetic review

Lia Monica Junie  1 , Ionuţ Isaia Jeican  1 , Luminiţa Matroş  1 , Stanca Lucia Pandrea  1
Affiliations
Review

Molecular epidemiology of the community-associated methicillin-resistant staphylococcus aureus clones: a synthetic review

Lia Monica Junie et al. Clujul Med. 2018.

Abstract

The article presents a synthetic molecular characterization of the methicillin-resistant Staphylococcus aureus and describes the most important community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clones that circulate nowadays in the world: the main molecular and epidemiological characteristics, as well as notions related to the clinic of infections produced by these clones and their antibiotic resistance spectrum. The predominant clone of CA-MRSA in North America is USA300 - ST8-IV in North America, in Australia - Queensland (Qld) MRSA (ST93-IV), in Europe - ST80-IV, in Asia there is a high heterogeneity of clones population, in Africa the distribution of CA-MRSA clones is unclear, and in South America - USA 1100 and USA300-Latin American variant are predominant. The molecular diagnosis is performed by highly specialized institutions. The knowledge of clones allows the study of antibiotic resistance spectrum for each one, a fact of great importance for medical practice. Molecular epidemiology of the CA-MRSA shows that lowly restricted sales of antibiotics in shops and pharmacies, as well as medical prescribing practices without a laboratory investigation, especially in Eastern Europe and Asia, contribute to the development of new MRSA clones with increased resistance to antibiotics.

Keywords: CA-MRSA; Staphylococcus aureus; clones.

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Figures

Figure 1
Figure 1
Schematic map of the main CA-MRSA clones.
See this image and copyright information in PMC

References

    1. Lowy FD. Staphylococcus aureus infections. N Engl J Med. 1998;339(8):520–532. - PubMed
    1. Feil EJ, Cooper JE, Grundmann H, Robinson DA, Enright MC, Berendt T, et al. How clonal is Staphylococcus aureus? J Bacteriol. 2003;185(11):3307–3316. - PMC - PubMed
    1. Jevons MP. “Celbenin”-resistant staphylococci. BMJ. 1961;1:124–125.
    1. David MZ, Daum RS. Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev. 2010;23(3):616–687. - PMC - PubMed
    1. Ellis MW, Hospenthal DR, Dooley DP, Gray PJ, Murray CK. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clin Infect Dis. 2004;39(7):971–979. - PubMed

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