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Review
. 2018 Feb 7;11(1):4.
doi: 10.1186/s40413-017-0182-z. eCollection 2018.

Food protein-induced enterocolitis syndrome: a review of the new guidelines

Stephanie A Leonard  1 , Valentina Pecora  2 , Alessandro Giovanni Fiocchi  2 , Anna Nowak-Wegrzyn  3
Affiliations
Review

Food protein-induced enterocolitis syndrome: a review of the new guidelines

Stephanie A Leonard et al. World Allergy Organ J. .

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated gastrointestinal food allergy that presents with delayed vomiting after ingestion primarily in infants. While the pathophysiology of FPIES is poorly understood, the clinical presentation of acute FPEIS reactions has been well characterized. The first International Consensus Guidelines for the Diagnosis and Management of Food Protein-induced Enterocolitis Syndrome were published in 2017 and reviewed epidemiology, clinical presentation, and prognosis of acute and chronic FPIES. The workgroup outlined clinical phenotypes, proposed diagnostic criteria, and made recommendations on management. This article summarizes the guidelines and adds recent updates. FPIES is gaining recognition, however there continues to be delays in diagnosis and misdiagnosis due to overlap of symptoms with over conditions, lack of a diagnostic test, and because some of the common trigger foods are not thought of as allergenic. More research into disease mechanisms and factors influencing differences between populations is needed.

Keywords: Cow’s milk allergy; FPIES; Food protein-induced enterocolitis syndrome; Gastrointestinal food allergy; Non-IgE mediated food allergy.

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Conflict of interest statement

Not applicable.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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