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Editorial
. 2018 Jan 15:3:4.
doi: 10.21037/tgh.2017.12.09. eCollection 2018.

Limited activity of metronomic cyclophosphamide and pembrolizumab for soft tissue sarcomas

Affiliations
Editorial

Limited activity of metronomic cyclophosphamide and pembrolizumab for soft tissue sarcomas

Irvin C Lien et al. Transl Gastroenterol Hepatol. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Comment on

References

    1. Tap WD, Jones RL, Van Tine BA, et al. Olaratumab and doxorubicin versus doxorubicin alone for treatment of soft-tissue sarcoma: an open-label phase 1b and randomised phase 2 trial. Lancet 2016;388:488-97. 10.1016/S0140-6736(16)30587-6 - DOI - PMC - PubMed
    1. Iwai Y, Hamanishi J, Chamoto K, et al. Cancer immunotherapies targeting the PD-1 signaling pathway. J Biomed Sci 2017;24:26. 10.1186/s12929-017-0329-9 - DOI - PMC - PubMed
    1. Pollack SM, He Q, Yearley JH, et al. T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas. Cancer 2017;123:3291-304. 10.1002/cncr.30726 - DOI - PMC - PubMed
    1. Tawbi HA, Burgess M, Bolejack V, et al. Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial. Lancet Oncol 2017;18:1493-501. 10.1016/S1470-2045(17)30624-1 - DOI - PMC - PubMed
    1. Que Y, Xiao W, Guan YX, et al. PD-L1 Expression Is Associated with FOXP3+ Regulatory T-Cell Infiltration of Soft Tissue Sarcoma and Poor Patient Prognosis. J Cancer 2017;8:2018-25. 10.7150/jca.18683 - DOI - PMC - PubMed

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