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. 2018 Feb 19;33(8):e65.
doi: 10.3346/jkms.2018.33.e65.

Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015

Ryoung Eun Ko #  1 , Seong Mi Moon #  1 , Soohyun Ahn  2 , Byung Woo Jhun  1 , Kyeongman Jeon  1 , O Jung Kwon  1 , Hee Jae Huh  3 , Chang Seok Ki  3 , Nam Yong Lee  3 , Won Jung Koh  4
Affiliations

Changing Epidemiology of Nontuberculous Mycobacterial Lung Diseases in a Tertiary Referral Hospital in Korea between 2001 and 2015

Ryoung Eun Ko et al. J Korean Med Sci. .

Abstract

This study investigated the changes in the major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period in Korea. The increase of number of patients with NTM-LD was primarily due to an increase of Mycobacterium avium complex (MAC) lung disease (LD). Among MAC cases, the proportion of M. avium increased compared with M. intracellulare, whereas the incidence of M. abscessus complex and M. kansasii LD remained relatively stable. The proportion of cases of the nodular bronchiectatic form increased compared with the fibrocavitary form of NTM-LD.

Keywords: Epidemiology; Mycobacterium abscessus; Mycobacterium avium Complex; Mycobacterium kansasii; Nontuberculous Mycobacteria; Republic of Korea.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Annual incidence of nontuberculous mycobacterial lung disease per 100,000 inpatient and outpatient encounters. MAC = Mycobacterium avium complex, MABC = Mycobacterium abscessus complex.
Fig. 2
Fig. 2
Changes in the proportion. (A) Mycobacterium avium and Mycobacterium intracellulare among patients with Mycobacterium avium complex lung disease. (B) Clinical phenotypes of nontuberculous mycobacterial lung disease.
See this image and copyright information in PMC

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