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. 2018 Mar;12(3):245-256.
doi: 10.2217/bmm-2017-0273. Epub 2018 Feb 14.

Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma

Mahmoud A Ali  1 , Marwa Matboli  2 , Nashwa El-Khazragy  3 , Osama Saber  4 , Sarah El-Nakeep  5 , Hana M Abdelzaher  6 , Ayman El-Sayed Shafei  1 , Randa Mostafa  1
Affiliations

Investigating miRNA-661 and ATG4-B mRNA expression as potential biomarkers for hepatocellular carcinoma

Mahmoud A Ali et al. Biomark Med. 2018 Mar.

Abstract

Aim: We aimed to examine the statistical association between serum expression of miRNA 661 (miR-661) and ATG-4B mRNA and hepatocellular carcinoma (HCC) based on in silico data analysis followed by clinical validation.

Patients & methods: Quantitative reverse-transcriptase real-time PCR was used to examine the expression of miR-661 and ATG-4B mRNA in the sera of HCC patients versus control.

Results: The expression of miR-661 and ATG-4B mRNA was positive in 97.14 and 77.14%, respectively, in HCC patients. The survival analysis showed that ATG-4B mRNA was an independent prognostic factor.

Conclusion: Our data are the first report of its kind regarding the considerable clinical significance of miR-661 and ATG-4B mRNA in HCC patients.

Keywords: ATG-4B; bioinformatics; biomarkers; hepatocellular carcinoma; miR-661; prognosis.

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