Photofluorination of Aliphatic C-H Bonds Promoted by the Phthalimide Group

Abstract

Aliphatic C-H fluorination of phthalimide derivatives with Selectfluor was investigated under photoirradiation conditions. The reaction did not require any additive or catalyst and afforded C-H fluorinated products in moderate to good yields. It is likely that the reaction site depends on the C-H bond energy, and this may be the reason for the good to high regioselectivity.