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Review
. 2018 Jul 1;315(1):F1-F6.
doi: 10.1152/ajprenal.00594.2017. Epub 2018 Feb 14.

Mechanisms of altered renal sodium handling in age-related hypertension

Alissa A Frame  1 , Richard D Wainford  1
Affiliations
Review

Mechanisms of altered renal sodium handling in age-related hypertension

Alissa A Frame et al. Am J Physiol Renal Physiol. .

Abstract

The prevalence of hypertension rises with age to approximately two out of three adults over the age of 60 in the United States. Although the mechanisms underlying age-related hypertension are incompletely understood, sodium homeostasis is critical to the long-term regulation of blood pressure and there is strong evidence that aging is associated with alterations in renal sodium handling. This minireview focuses on recent advancements in our understanding of the vascular, neurohumoral, and renal mechanisms that influence sodium homeostasis and promote age-related hypertension.

Keywords: aging; hypertension; renal sodium handling.

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