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Review
. 2018 Feb 14;6(1):17.
doi: 10.3390/healthcare6010017.

Ageing with HIV

Padraig McGettrick  1   2 , Elena Alvarez Barco  3 , Patrick W G Mallon  4   5
Affiliations
Review

Ageing with HIV

Padraig McGettrick et al. Healthcare (Basel). .

Abstract

The population of people living with HIV (PLWH) is growing older with an estimated 4 million over the age of 50 years, a figure which has doubled since the introduction of effective antiretroviral therapy (ART) and which is increasing globally. Despite effective ART, PLWH still experience excess morbidity and mortality compared to the general population with increased prevalence of age-related, non-AIDS illnesses (NAI) such as cardiovascular disease, malignancies, cognitive impairment and reduced bone mineral density, which impact disability and everyday functioning. This review will discuss the challenges presented by comorbidities in ageing PLWH and discuss the aetiology and management of age-related illnesses in this vulnerable population.

Keywords: HIV; ageing; cardiovascular disease; cognitive impairment; frailty; inflammation; malignancy; non-AIDS illness.

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Conflict of interest statement

P.W.G.M. is currently receiving a grant to his institution from GlaxoSmithKline (Ireland) and Gilead Sciences, is serving on advisory boards and speaking engagements for Gilead Sciences, Bristol Myers Squibb and Janssen Cilag, receives honoraria from Gilead Sciences, and has received honoraria from Gilead Sciences, Bristol Myers Squibb, Janseen Cilag and MSD. The remaining authors have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of literature search.
Figure 2
Figure 2
Inflammation and innate immune activation contribute to pathogenesis of CVD in PLWH.
See this image and copyright information in PMC

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