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Review
. 2019 Feb:86:24-35.
doi: 10.1016/j.semcdb.2018.02.014. Epub 2018 Feb 19.

Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

Solana Alculumbre  1 , Salvatore Raieli  1 , Caroline Hoffmann  1 , Rabie Chelbi  1 , François-Xavier Danlos  1 , Vassili Soumelis  2
Affiliations
Review

Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

Solana Alculumbre et al. Semin Cell Dev Biol. 2019 Feb.

Abstract

Plasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies.

Keywords: Adaptive immunity; Human diseases; Innate sensing; Plasmacytoid dendritic cells; Type I Interferon.

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