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Case Reports
. 2018 Feb 14:2018:bcr2017223154.
doi: 10.1136/bcr-2017-223154.

Isolated bladder schwannoma: a rare presentation

Samer Jallad  1 , Samir Ghani  1 , Mohammad Ali Omar  1 , Hanif Motiwala  1
Affiliations
Case Reports

Isolated bladder schwannoma: a rare presentation

Samer Jallad et al. BMJ Case Rep. .

Abstract

Bladder schwannoma is a rare tumour arising from Schwann cells in nerve sheaths. It is usually more common in patients diagnosed with neurofibromatosis. However, isolated cases of urinary bladder schwannoma is incredibly rare, attributing to <0.1% of bladder tumours. A literature review and analysis revealed that it presents in adulthood, is mostly symptomatic and diagnosis is established histologically. We report a case of isolated bladder schwannoma in 25 year-old female who presented with dyspareunia.

Keywords: peripheral nerve disease; urinary and genital tract disorders; urological surgery; urology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Pelvic ultrasound (top images) investigating dyspareunia revealed a bladder lesion. T1-weighted (lower left) and T2-weighted (lower right) MRIs showing intramural bladder lesion.
Figure 2
Figure 2
Cystoscopy revealed a bladder lesion with normal covering mucosa.
Figure 3
Figure 3
H&E staining revealed compact hypercellular Antoni A areas ‘spindle shaped cells arranged in fascicles’ (left). Immunohistochemical profile showed that these cells were S100-positive (middle) and CD56-positive (generally negative in neurofibroma and positive in schwannoma) (right), while negative for CD34, SMA, desmin, HMB 45, melan A, chromogranin, synaptophysin and calretinin suggesting the diagnosis of schwannoma.
See this image and copyright information in PMC

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