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Review
. 2018 Apr 25;56(5):e01909-17.
doi: 10.1128/JCM.01909-17. Print 2018 May.

Diagnosing Invasive Candidiasis

Cornelius J Clancy  1   2 , M Hong Nguyen  3
Affiliations
Review

Diagnosing Invasive Candidiasis

Cornelius J Clancy et al. J Clin Microbiol. .

Abstract

Cultures are negative in ∼50% of invasive candidiasis. Data are emerging for the performance of nonculture tests such as mannan/antimannan, Candida albicans germ tube antibody, 1,3-β-d-glucan, PCR, and the T2Candida panel in diagnosing both candidemia and deep-seated candidiasis. In most settings, positive predictive values of nonculture test are low, and negative predictive values are high. For tests to be useful, clinicians must understand the pretest likelihood of invasive candidiasis and test performance for the most common disease manifestation in a given patient. This paper reviews nonculture Candida diagnostics and discusses how they might be used effectively in patient care.

Keywords: T2Candida; T2MR; candidemia; candidiasis; diagnosis; intra-abdominal candidiasis.

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References

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