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. 2019 Apr;58(3):1033-1045.
doi: 10.1007/s00394-018-1619-z. Epub 2018 Feb 14.

Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk

Janneke G F Hogervorst  1   2 , Piet A van den Brandt  3 , Roger W L Godschalk  4 , Frederik-Jan van Schooten  4 , Leo J Schouten  3
Affiliations

Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk

Janneke G F Hogervorst et al. Eur J Nutr. 2019 Apr.

Abstract

Purpose: The association between dietary acrylamide intake and estrogen receptor-positive (ER+) breast cancer risk in epidemiological studies is inconsistent. By analyzing gene-acrylamide interactions for ER+ breast cancer risk, we aimed to clarify the role of acrylamide intake in ER+ breast cancer etiology.

Methods: The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline, a random subcohort of 2589 women was sampled from the total cohort for a case-cohort analysis approach. Dietary acrylamide intake of subcohort members (n = 1449) and ER+ breast cancer cases (n = 844) was assessed with a food frequency questionnaire. We genotyped single nucleotide polymorphisms (SNPs) in genes in acrylamide metabolism, sex steroid systems, oxidative stress and DNA repair. Multiplicative interaction between acrylamide intake and SNPs was assessed with Cox proportional hazards analysis, based on 20.3 years of follow-up.

Results: Unexpectedly, there was a statistically non-significant inverse association between acrylamide and ER+ breast cancer risk among all women but with no clear dose-response relationship, and no association among never smokers. Among the results for 57 SNPs and 2 gene deletions, rs1056827 in CYP1B1, rs2959008 and rs7173655 in CYP11A1, the GSTT1 gene deletion, and rs1052133 in hOGG1 showed a statistically significant interaction with acrylamide intake for ER+ breast cancer risk.

Conclusions: This study did not provide evidence for a positive association between acrylamide intake and ER+ breast cancer risk. If anything, acrylamide was associated with a decreased ER+ breast cancer risk. The interaction with SNPs in CYP1B1 and CYP11A1 suggests that acrylamide may influence ER+ breast cancer risk through sex hormone pathways.

Keywords: Dietary acrylamide; Estrogen receptor-positive breast cancer; Prospective cohort; Single nucleotide polymorphism.

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Conflict of interest statement

The authors have no conflict of interest to declare. Leo Schouten was compensated for being on an expert panel of the European Food Safety Authority that contributed to the 2015 risk assessment on acrylamide.

Figures

Fig. 1
Fig. 1
Flow chart of subcohort members and estrogen receptor-positive breast cancer cases
See this image and copyright information in PMC

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References

    1. Maier A, Kohrman-Vincent M, Hertzberg R, Allen B, Haber LT, Dourson M. Critical review of dose-response options for F344 rat mammary tumors for acrylamide - additional insights based on mode of action. Food Chem Toxicol. 2012;50(5):1763–1775. - PubMed
    1. Pelucchi C, Bosetti C, Galeone C, La Vecchia C. Dietary acrylamide and cancer risk: an updated meta-analysis. Int J Cancer. 2015;136(12):2912–2922. - PubMed
    1. Pedersen GS, Hogervorst JG, Schouten LJ, Konings EJ, Goldbohm RA, van den Brandt PA. Dietary acrylamide intake and estrogen and progesterone receptor-defined postmenopausal breast cancer risk. Breast Cancer Res Treat. 2010;122(1):199–210. - PubMed
    1. Olesen PT, Olsen A, Frandsen H, Frederiksen K, Overvad K, Tjonneland A. Acrylamide exposure and incidence of breast cancer among postmenopausal women in the Danish Diet, Cancer and Health Study. Int J Cancer. 2008;122(9):2094–2100. - PubMed
    1. Althuis MD, Fergenbaum JH, Garcia-Closas M, Brinton LA, Madigan MP, Sherman ME. Etiology of hormone receptor-defined breast cancer: a systematic review of the literature. Cancer Epidemiol Biomarkers Prev. 2004;13(10):1558–1568. - PubMed