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Comparative Study
. 2018 May:189:1-9.
doi: 10.1016/j.ajo.2018.02.002. Epub 2018 Feb 13.

Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients

Huiyuan Hou  1 , Takuhei Shoji  2 , Linda M Zangwill  1 , Sasan Moghimi  3 , Luke J Saunders  1 , Kyle Hasenstab  1 , Elham Ghahari  1 , Patricia Isabel C Manalastas  1 , Tadamichi Akagi  4 , Mark Christopher  1 , Rafaella C Penteado  1 , Robert N Weinreb  5
Affiliations
Comparative Study

Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients

Huiyuan Hou et al. Am J Ophthalmol. 2018 May.

Abstract

Purpose: To compare the rates of visual field (VF) loss and retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG) patients with or without type 2 diabetes mellitus (DM).

Design: Cohort study.

Methods: A total of 197 eyes (55 eyes of 32 POAG patients with DM in POAG/DM group and 142 eyes of 111 age-matched POAG patients without DM in POAG/DM- group) were included from the Diagnostic Innovations in Glaucoma Study (DIGS). Type 2 DM participants were defined by self-report of DM history and use of antidiabetic medication. The rates of VF loss and RNFL loss were compared in POAG eyes with and without DM using univariate and multivariable mixed-effects models.

Results: The median (interquartile range) follow-up was 5.7 years (4.0, 6.4). The mean rate of global RNFL loss in the POAG/DM group was 2-fold slower than in the POAG/DM- group overall (-0.40 μm/year vs -0.83 μm/year, respectively P = .01). Although a slower rate of VF mean deviation and pattern standard deviation loss was found in the POAG/DM group compared to the POAG/DM- group, the difference was not statistically significant.

Conclusions: POAG patients with treated type 2 DM, who had no detectable diabetic retinopathy, had significantly slower rates of RNFL thinning compared to those without diagnosed DM.

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Figures

Figure 1
Figure 1
Bar graph showing the distributions of the rates of mean deviation loss and global retinal nerve fiber layer thinning in eyes of POAG/DM and POAG//DM- patients. MD=mean deviation; RNFL= retinal nerve fiber layer.
Figure 1
Figure 1
Bar graph showing the distributions of the rates of mean deviation loss and global retinal nerve fiber layer thinning in eyes of POAG/DM and POAG//DM- patients. MD=mean deviation; RNFL= retinal nerve fiber layer.
See this image and copyright information in PMC

References

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