Chemical genetics in tumor lipogenesis

Abstract

Since cancer cells depend on de novo lipogenesis for energy supply, highly active membrane biosynthesis and signaling, enhanced fatty acid synthesis is a crucial characteristic of cancer cells. Hence, targeting lipogenic enzymes and signaling cascades is a very promising approach in developing innovative therapeutic agents for the fight against cancer. This review summarizes main aspects of altered fatty acid synthesis in cancer cells and emphasizes the power of chemical genetic approaches in identifying and analyzing novel anti-cancer drug candidates interfering with lipid metabolism.

Keywords: Acetyl-CoA carboxylase; Cancer therapy; Chemical genetics; Fatty acid synthase; Lipid metabolism; Lipogenesis.